Express v5 has been released and it's not supported: https://github.com/open-telemetry/opentelemetry-js-contrib/blob/80c2f1af6139e43522a944ab496fed68ef912fb2/plugins/node/opentelemetry-instrumentation-express/src/instrumentation.ts#L61-L62 I'm looking into the changes required so you can assign this issue to me!