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Added pcr-indel-model param for GATK HaplotypeCaller #1841

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Merged
merged 5 commits into from
Mar 25, 2025

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kjellinjonas
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Introduces a parameter to configure the pcr-indel-model in GATK HaplotypeCaller. The default "CONSERVATIVE" setting is not ideal for e.g. PCR-free libraries. Allowing users to change this improves indel calling accuracy for such libraries.

PR checklist

  • This comment contains a description of changes (with reason).
  • If you've fixed a bug or added code that should be tested, add tests!
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  • If necessary, also make a PR on the nf-core/sarek branch on the nf-core/test-datasets repository.
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  • Ensure the test suite passes (nextflow run . -profile test,docker --outdir <OUTDIR>).
  • Check for unexpected warnings in debug mode (nextflow run . -profile debug,test,docker --outdir <OUTDIR>).
  • Usage Documentation in docs/usage.md is updated.
  • Output Documentation in docs/output.md is updated.
  • CHANGELOG.md is updated.
  • README.md is updated (including new tool citations and authors/contributors).

maxulysse and others added 2 commits February 18, 2025 09:44
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## PR checklist

- [ ] This comment contains a description of changes (with reason).
- [ ] If you've fixed a bug or added code that should be tested, add
tests!
- [ ] If you've added a new tool - have you followed the pipeline
conventions in the [contribution
docs](https://github.com/nf-core/sarek/tree/master/.github/CONTRIBUTING.md)
- [ ] If necessary, also make a PR on the nf-core/sarek _branch_ on the
[nf-core/test-datasets](https://github.com/nf-core/test-datasets)
repository.
- [ ] Make sure your code lints (`nf-core pipelines lint`).
- [ ] Ensure the test suite passes (`nextflow run . -profile test,docker
--outdir <OUTDIR>`).
- [ ] Check for unexpected warnings in debug mode (`nextflow run .
-profile debug,test,docker --outdir <OUTDIR>`).
- [ ] Usage Documentation in `docs/usage.md` is updated.
- [ ] Output Documentation in `docs/output.md` is updated.
- [ ] `CHANGELOG.md` is updated.
- [ ] `README.md` is updated (including new tool citations and
authors/contributors).

---------

Co-authored-by: Friederike Hanssen <[email protected]>
Co-authored-by: Friederike Hanssen <[email protected]>
Co-authored-by: tdanhorn <[email protected]>
Co-authored-by: Thomas <[email protected]>
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github-actions bot commented Mar 24, 2025

Warning

Newer version of the nf-core template is available.

Your pipeline is using an old version of the nf-core template: 3.0.2.
Please update your pipeline to the latest version.

For more documentation on how to update your pipeline, please see the nf-core documentation and Synchronisation documentation.

@kjellinjonas kjellinjonas changed the base branch from master to dev March 24, 2025 12:32
@FriederikeHanssen
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Hey! I think you might be running of a n old dev branch. BEfore you continue, maybe merge dev into your current branch to cut down on changed files and get all those merge conflicts resolved.

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This looks good. Can you update the changelog please?

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@FriederikeHanssen FriederikeHanssen left a comment

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Nice one!

@FriederikeHanssen
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@kjellinjonas can you merge dev again? I have the feeling the failing tests are related to that

@FriederikeHanssen FriederikeHanssen merged commit 5888a93 into nf-core:dev Mar 25, 2025
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3 participants