mthfr-and-friends

A repository for the ap ms analysis of MTHFR interactions for the paper: "Evidence for Interaction of 5,10-Methylenetetrahydrofolate Reductase (MTHFR) with Methylenetetrahydrofolate Dehydrogenase (MTHFD1) and General Control Nonderepressible 1 (GCN1)" available as preprint on: https://www.biorxiv.org/content/10.1101/2024.08.22.609157v1

How to run the analysis

Development

This analysis requires conda to run.

Install it eg by following the miniforge tutorial: https://github.com/conda-forge/miniforge

Preparation

Install the mthfr-and-friends conda environment using:

mamba env create -n mthfr-and-friends -f environment.yml

Activate the environment using

conda activate mthfr-and-friends

Run the analysis

To run the complete analysis activate the conda environment and run

snakemake -c4 --sdm conda

To create the anlysis report run:

snakemake -c4 --sdm conda --report report.html