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Copy file name to clipboardExpand all lines: README.md
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**Multi-step pipeline dedicated to genetic imputation from simulation to validation**
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[](https://github.com/nf-core/phaseimpute/actions/workflows/ci.yml)[](https://github.com/nf-core/phaseimpute/actions/workflows/linting.yml)[](https://nf-co.re/phaseimpute/results)[](https://doi.org/10.5281/zenodo.14329225)[](https://www.nf-test.com)
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[](https://github.com/nf-core/phaseimpute/actions/workflows/ci.yml)
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[](https://github.com/nf-core/phaseimpute/actions/workflows/linting.yml)[](https://nf-co.re/phaseimpute/results)[](https://doi.org/10.5281/zenodo.14329225)[](https://www.nf-test.com)
[](https://docs.conda.io/en/latest/)
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[](https://www.docker.com/)
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## Usage
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> [!NOTE]
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> If you are new to Nextflow and nf-core, please refer to [this page](https://nf-co.re/docs/usage/installation) on how to set-up Nextflow.Make sure to [test your setup](https://nf-co.re/docs/usage/introduction#how-to-run-a-pipeline) with `-profile test` before running the workflow on actual data.
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> If you are new to Nextflow and nf-core, please refer to [this page](https://nf-co.re/docs/usage/installation) on how to set-up Nextflow.Make sure to [test your setup](https://nf-co.re/docs/usage/introduction#how-to-run-a-pipeline) with `-profile test` before running the workflow on actual data.
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The primary function of this pipeline is to impute a target dataset based on a phased panel. Begin by preparing a samplesheet with your input data, formatted as follows:
Copy file name to clipboardExpand all lines: docs/usage.md
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> [!IMPORTANT]
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> We highly recommend the use of Docker or Singularity containers for full pipeline reproducibility, however when this is not possible, Conda is also supported.
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The pipeline also dynamically loads configurations from [https://github.com/nf-core/configs](https://github.com/nf-core/configs) when it runs, making multiple config profiles for various institutional clusters available at run time. For more information and to check if your system is suported, please see the [nf-core/configs documentation](https://github.com/nf-core/configs#documentation).
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The pipeline also dynamically loads configurations from [https://github.com/nf-core/configs](https://github.com/nf-core/configs) when it runs, making multiple config profiles for various institutional clusters available at run time. For more information and to check if your system is supported, please see the [nf-core/configs documentation](https://github.com/nf-core/configs#documentation).
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Note that multiple profiles can be loaded, for example: `-profile test,docker` - the order of arguments is important!
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They are loaded in sequence, so later profiles can overwrite earlier profiles.
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