Trailing spaces and new lines

Author: DimitriPapadopoulos

_collections/_labs/ciel_animal-facility.md

@@ -4,7 +4,7 @@ title: ANIMAL FACILITY & WELFARE
 cat: ciel
 subcat: cell
 headline: Research topic
-teasing: Difficulty on insensible reasonable in. From as went he they. Preference themselves me as thoroughly partiality considered on in estimating. Middletons acceptance discovered projecting so is so or. In or attachment inquietude remarkably comparison at an. Is surrounded prosperous stimulated am me discretion expression. But truth being state can she china widow. Occasional preference fat remarkably now projecting uncommonly dissimilar. Sentiments projection particular companions interested do at my delightful. Listening newspaper in advantage frankness to concluded unwilling. 
+teasing: Difficulty on insensible reasonable in. From as went he they. Preference themselves me as thoroughly partiality considered on in estimating. Middletons acceptance discovered projecting so is so or. In or attachment inquietude remarkably comparison at an. Is surrounded prosperous stimulated am me discretion expression. But truth being state can she china widow. Occasional preference fat remarkably now projecting uncommonly dissimilar. Sentiments projection particular companions interested do at my delightful. Listening newspaper in advantage frankness to concluded unwilling.
 leader: Sébastien Mériaux
 icon:
 added: 2020

_collections/_labs/ciel_animal-mri.md

@@ -24,4 +24,4 @@ The 11.7T preclinical MRI scanner, running under the responsibility of F. Boumez
 
 The 17.2T preclinical MRI scanner, running under the responsibility of L. Ciobanu from the “NeuroPhysics” research group, is one of the highest magnetic field horizontal bore preclinical system in the world. The clear bore inside the gradients (85 mm) allows the imaging of small animals (rats, mice). Besides the very high magnetic field, another feature of this system is the high strength of the magnetic field gradients, capable of reaching 1000 mT/m. With these gradients, it is possible to acquire very high spatial resolution images (25 µm isotropic). The 17.2T system is equipped with a variety of radiofrequency coils: surface, phased array and volume coils for rat and mouse brain imaging, as well as with microcoils with diameters between 700 µm and 2 mm for imaging small samples. X nuclei surface coils (13C, 31P) for spectroscopy studies are also available.
 
-The system will be soon equipped with the AVANCE NEO electronics that offers improved shimming performances, faster gradient switching times and gradient linearity corrections ensuring better image quality. Secondly, a cryo-platform and a cryo-cooled deuterium coil (2H) will be purchased to open the way to novel explorations of metabolic events occurring in the brain. A helium recovery and liquefaction system will be installed to eliminate the need for helium supplies. 
+The system will be soon equipped with the AVANCE NEO electronics that offers improved shimming performances, faster gradient switching times and gradient linearity corrections ensuring better image quality. Secondly, a cryo-platform and a cryo-cooled deuterium coil (2H) will be purchased to open the way to novel explorations of metabolic events occurring in the brain. A helium recovery and liquefaction system will be installed to eliminate the need for helium supplies.

_collections/_labs/ciel_ciclops.md

@@ -22,8 +22,8 @@ Beyond the signal of <sup>1</sup>H<sub>2</sub>O, in vivo NMR of 1H and low gyrom
 
 While <sup>1</sup>H<sub>2</sub>O is the focus of almost all MRI studies, several other molecules and ions exist whose NMR signals are much more informative regarding the biophysical, metabolic or physiological status of those tissues. Over the past years, I used <sup>1</sup>H and <sup>31</sup>P NMR Spectroscopy to quantify metabolites involved in neurotransmission and metabolism, such as neurotransmitters Glutamate and GABA or energy store/substrates Adenosine Tri-Phosphate and Lactate. Using dedicated fast ultra-short echo-time imaging sequences, I also investigated Sodium (<sup>23</sup>Na) ions whose transmembrane concentration gradient is maintained at great energy cost and plays a major role in establishing the neurons’ resting potential.
 
-One of my recent research line is Lithium-7 MRI. Lithium salts are the main treatment for bipolar disorder, yet the mechanism of action remains a mystery, and 7Li MRI is the only technique allowing lithium non- invasive mapping and quantification in the brain. Dynamic <sup>13</sup>C or <sup>2</sup>H NMR are very interesting non-irradiating alternatives to \[18F]FDG-PET benefitting from their greater chemical/spectral specificities notably to discriminate and quantify aerobic vs. anaerobic energy synthesis pathways, neuronal and glial metabolism or even probe neurotransmission via the GABA and Glutamate synthesis and recycling rates. All of those weak signals benefit from the extremely high magnetic fields available at NeuroSpin enabling their investigation at better temporal and spatial resolutions. 
+One of my recent research line is Lithium-7 MRI. Lithium salts are the main treatment for bipolar disorder, yet the mechanism of action remains a mystery, and 7Li MRI is the only technique allowing lithium non- invasive mapping and quantification in the brain. Dynamic <sup>13</sup>C or <sup>2</sup>H NMR are very interesting non-irradiating alternatives to \[18F]FDG-PET benefitting from their greater chemical/spectral specificities notably to discriminate and quantify aerobic vs. anaerobic energy synthesis pathways, neuronal and glial metabolism or even probe neurotransmission via the GABA and Glutamate synthesis and recycling rates. All of those weak signals benefit from the extremely high magnetic fields available at NeuroSpin enabling their investigation at better temporal and spatial resolutions.
 
 My goal is to advance those methods and collaborate with biologists, physicians, bio-informaticians and neuroscientists to incorporate them within multimodal clinical and preclinical research protocols to better understand psychiatric and neurological diseases, their eventual treatments, and to develop novel biomarkers of disease progression or response to treatment.
 
-In January 2024, Alfredo Lopez-Kolkovsky joined the CICLOPS group to accelerate the development of metabolic neuroimaging in particular on the 11.7T Iseult scanner.
+In January 2024, Alfredo Lopez-Kolkovsky joined the CICLOPS group to accelerate the development of metabolic neuroimaging in particular on the 11.7T Iseult scanner.

_collections/_labs/ciel_histology.md

@@ -59,7 +59,7 @@ The two most relevant ones (<5 years):
 - Jelescu, I.O., de Skowronski, A., Geffroy, F., Palomboe, M., Novikov, D. S., (2022)  Neurite Exchange Imaging (NEXI): A minimal model of diffusion in gray matter with inter-compartment water exchange Neuroimage 119277 2022
 https://doi.org/10.1016/j.neuroimage.2022.119277
 
-- Conti, A., Geffroy, F., Kamimura, H. A. S., Novell, A., Tournier, N., Mériaux, S.  and Larrat, B. (2023) Regulation of P-glycoprotein and Breast Cancer Resistance Protein Expression Induced by Focused Ultrasound-Mediated Blood-Brain Barrier Disruption: A Pilot Study. International Journal of Molecular Sciences. 23, 15488 2022/ Int. J. Mol. Sci. 2022, 23, 15488. 
+- Conti, A., Geffroy, F., Kamimura, H. A. S., Novell, A., Tournier, N., Mériaux, S.  and Larrat, B. (2023) Regulation of P-glycoprotein and Breast Cancer Resistance Protein Expression Induced by Focused Ultrasound-Mediated Blood-Brain Barrier Disruption: A Pilot Study. International Journal of Molecular Sciences. 23, 15488 2022/ Int. J. Mol. Sci. 2022, 23, 15488.
 https://doi.org/10.3390/ijms232415488
 
 

_collections/_labs/ciel_midas.md

@@ -4,7 +4,7 @@ title: MIDAS
 cat: ciel
 subcat: team
 headline: Research topic
-teasing: The blood-brain barrier (BBB) remains the bottleneck for pharmacological therapy of neurological diseases, costing billionsto our societies.The goal of our team isto provide new solutionsto deliver drugsto the brain in a safe way in order to increase their efficacy on the target.Transcranial focused ultrasound isa particularly promising technique to transiently and locally disrupt thisvascular barrier. Since 2010,we use neuroimaging to characterize the technology and to develop translational strategies. We now aim at making it a reality for the highest possible number of patients in the future years. 
+teasing: The blood-brain barrier (BBB) remains the bottleneck for pharmacological therapy of neurological diseases, costing billionsto our societies.The goal of our team isto provide new solutionsto deliver drugsto the brain in a safe way in order to increase their efficacy on the target.Transcranial focused ultrasound isa particularly promising technique to transiently and locally disrupt thisvascular barrier. Since 2010,we use neuroimaging to characterize the technology and to develop translational strategies. We now aim at making it a reality for the highest possible number of patients in the future years.
 leader: Benoit Larrat
 icon: midas-icon.png
 added: 2020
@@ -22,4 +22,4 @@ In the last years, our team	has pursued technological developments as well as pr
 To be able to better model drug delivery, we have measured the diffusion properties of nanoparticles after their crossing of the BBB. On the technological side, we have implemented passive cavitation detection and feedback loop monitoring at high frame rate to ensure safety of the ultrasound procedure with a patented approach. We also introduced safe large volume BBB opening sequences for applications such as whole brain or hemispherical drug delivery.
 
 Regarding applications, we have demonstrated the interest of the technique in small animal models, mainly in neuro-oncology, Alzheimer’s disease and gene delivery fields. We showed the capabilities to increase significantly the local concentration of MRI contrast agents and PET tracers, of drug-loaded nanoparticles, of therapeutic antibodies and of adeno- associated viruses. To translate this to patients, we have built a public-private French consortium to design, assemble, and test a new prototype of clinical device. This system is robotized and neuro-navigated to make
-it widely spreadable in hospitals. It is cost-effective and compatible with short ambulatory procedures in order to perform chronic sessions over months or years. During the course of this project, every technological feature has been validated in non-human primates. We now want to pursue its clinical development through a spin-off company.
+it widely spreadable in hospitals. It is cost-effective and compatible with short ambulatory procedures in order to perform chronic sessions over months or years. During the course of this project, every technological feature has been validated in non-human primates. We now want to pursue its clinical development through a spin-off company.

_collections/_people/ciel_a-lopezkolkovsky.md

@@ -7,4 +7,3 @@ subcat: ciclops
 avatar: a-lopezkolkovsky.png
 joined: 2024
 ---
-

_collections/_people/ciel_b-larrat.md

@@ -7,4 +7,3 @@ subcat: midas
 avatar: b-larrat.png
 joined: 2006
 ---
-

_collections/_people/ciel_c-ressam.md

@@ -4,7 +4,6 @@ name: Camélia Ressam
 position: gradstudent
 cat: ciel
 subcat: neurophysics
-avatar: 
+avatar:
 joined: 2023
 ---
-

_collections/_people/ciel_d-boido.md

@@ -8,4 +8,3 @@ avatar: d-boido.png
 site: https://davideboido.github.io
 joined: 2020
 ---
-

_collections/_people/ciel_d-lebihan.md

@@ -7,4 +7,3 @@ subcat: neurophysics
 avatar: d-lebihan.png
 joined: 2006
 ---
-

_collections/_people/ciel_e-selingue.md

@@ -7,4 +7,3 @@ subcat: midas
 avatar: e-selingue.png
 joined: 2006
 ---
-

_collections/_people/ciel_f-boumezbeur.md

@@ -7,4 +7,3 @@ subcat: ciclops
 avatar: f-boumezbeur.png
 joined: 2006
 ---
-

_collections/_people/ciel_f-geffroy.md

@@ -4,7 +4,6 @@ name: Françoise Geffroy
 position: pi
 cat: ciel
 subcat: midas
-avatar: 
+avatar:
 joined: 2006
 ---
-

_collections/_people/ciel_g-pagé.md

@@ -7,4 +7,3 @@ subcat: midas
 avatar: g-page.png
 joined: 2024
 ---
-

_collections/_people/ciel_l-ciobanu.md

@@ -7,4 +7,3 @@ subcat: neurophysics
 avatar: l-ciobanu.png
 joined: 2006
 ---
-

_collections/_people/ciel_m-gay.md

@@ -4,7 +4,6 @@ name: Marion Gay
 position: engineer
 cat: ciel
 subcat: midas
-avatar: 
+avatar:
 joined: 2022
 ---
-

_collections/_people/ciel_m-glatigny.md

@@ -7,4 +7,3 @@ subcat: midas
 avatar: m-glatigny.png
 joined: 2022
 ---
-

_collections/_people/ciel_r-gaudin.md

@@ -7,4 +7,3 @@ subcat: neurophysics
 avatar: r-gaudin.png
 joined: 2023
 ---
-

_collections/_people/ciel_s-meriaux.md

@@ -7,4 +7,3 @@ subcat: midas
 avatar: s-meriaux.png
 joined: 2006
 ---
-

_collections/_people/ciel_t-tsurugizawa.md

@@ -7,4 +7,3 @@ subcat: neurophysics
 avatar:
 joined: 2006
 ---
-

_collections/_people/ciel_w-pianezzola.md

@@ -4,7 +4,6 @@ name: Wilfried Pianezzola
 position: engineer
 cat: ciel
 subcat: midas
-avatar: 
+avatar:
 joined: 2006
 ---
-

biblio_other.md

@@ -34,7 +34,7 @@ permalink: bibliography.html
         {% if entry.doi %}
           {% capture title %}<a href="http://doi.org/{{entry.doi}}" target="_blank">{{entry.title}}</a>{% endcapture %}
         {% else %}
-          {% assign title = {{entry.title}} %}  
+          {% assign title = {{entry.title}} %}
         {% endif %}
         {% if entry.journal %}
             {{entry.author}}: {{title}}, {{entry.journal}} ({{entry.year}})
@@ -51,4 +51,3 @@ permalink: bibliography.html
 <hr>
 
 {% endfor %}
-

biblio_selected.md

@@ -19,7 +19,7 @@ permalink: bibliography/bestof.html
         {% if entry.doi %}
           {% capture title %}<a href="http://doi.org/{{entry.doi}}" target="_blank">{{entry.title}}</a>{% endcapture %}
         {% else %}
-          {% assign title = {{entry.title}} %}  
+          {% assign title = {{entry.title}} %}
         {% endif %}
         {% if entry.journal %}
             {{entry.author}}: {{title}}, {{entry.journal}} ({{entry.year}})
@@ -34,5 +34,3 @@ permalink: bibliography/bestof.html
   {% endfor %}
 </div>
 <hr>
-
-

index.md

@@ -18,7 +18,7 @@ layout: page_lab
     </ul>
   </p>
   <p>
-    Therefore, the global scientific strategy of CIEL consists in building a framework of imaging technologies that are increasing the comprehension of fundamental mechanisms underlying brain functioning, but also in producing new diagnostic and therapeutic tools in a pathological context such as brain tumor, stroke, neurodegenerative and psychiatric diseases. 
+    Therefore, the global scientific strategy of CIEL consists in building a framework of imaging technologies that are increasing the comprehension of fundamental mechanisms underlying brain functioning, but also in producing new diagnostic and therapeutic tools in a pathological context such as brain tumor, stroke, neurodegenerative and psychiatric diseases.
   </p>
   <p>
   Below is a list of all the <a href="#teams">teams</a> and <a href="#cells">cells</a>. A <a href="#gallery">gallery</a> of current research topics is also available.
@@ -51,4 +51,3 @@ layout: page_lab
   "/>
 </div>
 </section>
-

members.md

@@ -18,8 +18,8 @@ permalink: /people/
     {% endfor %}
     {% assign people_valid = people_valid | push: listpeople %}
 {% endfor %}
- 
- 
+
+
 <div>
 {% assign i = 0 %}
 {% for item in people_array %}

opportunities.md

@@ -29,7 +29,7 @@ For a spontaneous application do not hesitate to <a href="mailto:{{site.email}}"
     {% endfor %}
     {% assign jobs_valid = jobs_valid | push: listjobs %}
 {% endfor %}
- 
+
 <div>
 {% assign i = 0 %}
 {% for item in jobs_array %}
@@ -68,4 +68,3 @@ For a spontaneous application do not hesitate to <a href="mailto:{{site.email}}"
     {% endif %}
 {% endfor %}
 </div>
-