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Welcome to the Neuropixels User Guide wiki

This website is intended as a practical user's guide to the use of Neuropixels Phase3 electrode arrays and the analysis of data they produce.

The information in the IMEC-supplied user manual supersedes anything on this website, so please reference that document first. You must obtain a copy of this manual from the IMEC svn repository (contact Tim Harris for a username and password).

The information provided here comes from users of the Neuropixels testers consortium, and should be taken as-is, and at your own risk. No one involved in the creation of this resource is responsible for your experiments working or your probes remaining intact.

Getting Started

• About Neuropixels - probe description, terminology
• Equipment List
• Probe handling/mounting

Acquiring data

• Acquisition software
• Referencing
• Gain settings
• Filter settings
• Impedance testing
• Synchronization

Processing data

• Recommended preprocessing
• Spike sorting
• Other analysis methods

Miscellaneous

• Probe care
• Approved solutions list - which liquids/chemicals your probe can come into contact with
• Identifying tracks in histology

Thanks to Josh Siegle, who contributed some graphics and text to this resource.