diff --git a/instrumentation/jdbc/library/src/main/java/io/opentelemetry/instrumentation/jdbc/internal/JdbcConnectionUrlParser.java b/instrumentation/jdbc/library/src/main/java/io/opentelemetry/instrumentation/jdbc/internal/JdbcConnectionUrlParser.java
index dedd913d2b5c..aefab211aafc 100644
--- a/instrumentation/jdbc/library/src/main/java/io/opentelemetry/instrumentation/jdbc/internal/JdbcConnectionUrlParser.java
+++ b/instrumentation/jdbc/library/src/main/java/io/opentelemetry/instrumentation/jdbc/internal/JdbcConnectionUrlParser.java
@@ -829,6 +829,62 @@ DbInfo.Builder doParse(String jdbcUrl, DbInfo.Builder builder) {
 
       return MODIFIED_URL_LIKE.doParse(jdbcUrl, builder);
     }
+  },
+  INFORMIX_SQLI("informix-sqli") {
+    private static final int DEFAULT_PORT = 9088;
+
+    @Override
+    DbInfo.Builder doParse(String jdbcUrl, DbInfo.Builder builder) {
+      builder = MODIFIED_URL_LIKE.doParse(jdbcUrl, builder);
+
+      DbInfo dbInfo = builder.build();
+      if (dbInfo.getPort() == null) {
+        builder.port(DEFAULT_PORT);
+      }
+
+      int hostIndex = jdbcUrl.indexOf("://");
+      if (hostIndex == -1) {
+        return builder;
+      }
+
+      int dbNameStartIndex = jdbcUrl.indexOf('/', hostIndex + 3);
+      if (dbNameStartIndex == -1) {
+        return builder;
+      }
+      int dbNameEndIndex = jdbcUrl.indexOf(':', dbNameStartIndex);
+      if (dbNameEndIndex == -1) {
+        dbNameEndIndex = jdbcUrl.length();
+      }
+      String name = jdbcUrl.substring(dbNameStartIndex + 1, dbNameEndIndex);
+      if (name.isEmpty()) {
+        builder.name(null);
+      } else {
+        builder.name(name);
+      }
+
+      return builder;
+    }
+  },
+
+  INFORMIX_DIRECT("informix-direct") {
+    private final Pattern pattern = Pattern.compile("://(.*?)(:|;|$)");
+
+    @Override
+    DbInfo.Builder doParse(String jdbcUrl, DbInfo.Builder builder) {
+      builder = MODIFIED_URL_LIKE.doParse(jdbcUrl, builder);
+      builder.host(null);
+      builder.port(null);
+
+      Matcher matcher = pattern.matcher(jdbcUrl);
+      if (matcher.find()) {
+        String name = matcher.group(1);
+        if (!name.isEmpty()) {
+          builder.name(name);
+        }
+      }
+
+      return builder;
+    }
   };
 
   private static final Logger logger = Logger.getLogger(JdbcConnectionUrlParser.class.getName());
@@ -998,6 +1054,10 @@ private static String toDbSystem(String type) {
         return DbSystemValues.H2;
       case "hsqldb": // Hyper SQL Database
         return "hsqldb";
+      case "informix-sqli": // IBM Informix
+        return DbSystemValues.INFORMIX_SQLI;
+      case "informix-direct":
+        return DbSystemValues.INFORMIX_DIRECT;
       case "mariadb": // MariaDB
         return DbSystemValues.MARIADB;
       case "mysql": // MySQL
@@ -1024,6 +1084,8 @@ private static final class DbSystemValues {
     static final String MYSQL = "mysql";
     static final String ORACLE = "oracle";
     static final String DB2 = "db2";
+    static final String INFORMIX_SQLI = "informix-sqli";
+    static final String INFORMIX_DIRECT = "informix-direct";
     static final String POSTGRESQL = "postgresql";
     static final String HANADB = "hanadb";
     static final String DERBY = "derby";
diff --git a/instrumentation/jdbc/library/src/test/java/io/opentelemetry/instrumentation/jdbc/internal/JdbcConnectionUrlParserTest.java b/instrumentation/jdbc/library/src/test/java/io/opentelemetry/instrumentation/jdbc/internal/JdbcConnectionUrlParserTest.java
index feccb1ee512b..c4a41ca631fd 100644
--- a/instrumentation/jdbc/library/src/test/java/io/opentelemetry/instrumentation/jdbc/internal/JdbcConnectionUrlParserTest.java
+++ b/instrumentation/jdbc/library/src/test/java/io/opentelemetry/instrumentation/jdbc/internal/JdbcConnectionUrlParserTest.java
@@ -638,6 +638,63 @@ public Stream<? extends Arguments> provideArguments(ExtensionContext context) {
               .setDb("sapdb")
               .build(),
 
+          // https://www.ibm.com/support/pages/how-configure-informix-jdbc-connection-string-connect-group
+          arg("jdbc:informix-sqli://infxhost:99/infxdb:INFORMIXSERVER=infxsn;user=infxuser;password=PW")
+              .setSystem("informix-sqli")
+              .setUser("infxuser")
+              .setShortUrl("informix-sqli://infxhost:99")
+              .setHost("infxhost")
+              .setPort(99)
+              .setName("infxdb")
+              .build(),
+          arg("jdbc:informix-sqli://localhost:9088/stores_demo:INFORMIXSERVER=informix")
+              .setSystem("informix-sqli")
+              .setShortUrl("informix-sqli://localhost:9088")
+              .setHost("localhost")
+              .setPort(9088)
+              .setName("stores_demo")
+              .build(),
+          arg("jdbc:informix-sqli://infxhost:99")
+              .setSystem("informix-sqli")
+              .setShortUrl("informix-sqli://infxhost:99")
+              .setHost("infxhost")
+              .setPort(99)
+              .build(),
+          arg("jdbc:informix-sqli://infxhost/")
+              .setSystem("informix-sqli")
+              .setShortUrl("informix-sqli://infxhost:9088")
+              .setHost("infxhost")
+              .setPort(9088)
+              .build(),
+          arg("jdbc:informix-sqli:")
+              .setSystem("informix-sqli")
+              .setShortUrl("informix-sqli:")
+              .setPort(9088)
+              .build(),
+
+          // https://www.ibm.com/docs/en/informix-servers/12.10?topic=method-format-database-urls
+          arg("jdbc:informix-direct://infxdb:999;user=infxuser;password=PW")
+              .setSystem("informix-direct")
+              .setShortUrl("informix-direct:")
+              .setUser("infxuser")
+              .setName("infxdb")
+              .build(),
+          arg("jdbc:informix-direct://infxdb;user=infxuser;password=PW")
+              .setSystem("informix-direct")
+              .setShortUrl("informix-direct:")
+              .setUser("infxuser")
+              .setName("infxdb")
+              .build(),
+          arg("jdbc:informix-direct://infxdb")
+              .setSystem("informix-direct")
+              .setShortUrl("informix-direct:")
+              .setName("infxdb")
+              .build(),
+          arg("jdbc:informix-direct:")
+              .setSystem("informix-direct")
+              .setShortUrl("informix-direct:")
+              .build(),
+
           // http://www.h2database.com/html/features.html#database_url
           arg("jdbc:h2:mem:").setShortUrl("h2:mem:").setSystem("h2").setSubtype("mem").build(),
           arg("jdbc:h2:mem:")