diff --git a/src/coreclr/jit/gentree.cpp b/src/coreclr/jit/gentree.cpp
index af9cea738e7682..17ca0e3a46b1da 100644
--- a/src/coreclr/jit/gentree.cpp
+++ b/src/coreclr/jit/gentree.cpp
@@ -19978,12 +19978,17 @@ bool GenTree::SupportsSettingZeroFlag()
     }
 #endif
 #elif defined(TARGET_ARM64)
-    if (OperIs(GT_AND, GT_AND_NOT, GT_NEG))
+    if (OperIs(GT_AND, GT_AND_NOT))
     {
         return true;
     }
 
     // We do not support setting zero flag for madd/msub.
+    if (OperIs(GT_NEG) && (!gtGetOp1()->OperIs(GT_MUL) || !gtGetOp1()->isContained()))
+    {
+        return true;
+    }
+
     if (OperIs(GT_ADD, GT_SUB) && (!gtGetOp2()->OperIs(GT_MUL) || !gtGetOp2()->isContained()))
     {
         return true;
diff --git a/src/tests/JIT/Regression/JitBlue/Runtime_113320/Runtime_113320.cs b/src/tests/JIT/Regression/JitBlue/Runtime_113320/Runtime_113320.cs
new file mode 100644
index 00000000000000..3fe568b9c0d060
--- /dev/null
+++ b/src/tests/JIT/Regression/JitBlue/Runtime_113320/Runtime_113320.cs
@@ -0,0 +1,36 @@
+// Licensed to the .NET Foundation under one or more agreements.
+// The .NET Foundation licenses this file to you under the MIT license.
+
+// Generated by Fuzzlyn v2.4 on 2025-03-09 16:30:39
+// Run on Arm64 Linux
+// Seed: 8543882715922286200-vectort,vector64,vector128,armadvsimd,armadvsimdarm64,armaes,armarmbase,armarmbasearm64,armcrc32,armcrc32arm64,armdp,armrdm,armrdmarm64,armsha1,armsha256,armsve
+// Reduced from 59.2 KiB to 0.4 KiB in 00:00:34
+// Debug: Outputs 0
+// Release: Outputs 1
+using System;
+using System.Numerics;
+using System.Runtime.Intrinsics;
+using System.Runtime.Intrinsics.Arm;
+using Xunit;
+
+public class Runtime_113320
+{
+    public static ushort s_12;
+    public static uint[, ] s_13 = new uint[, ]
+    {
+        {
+            1
+        }
+    };
+    
+    [Fact]
+    public static int Problem()
+    {
+        if (((0 % s_13[0, 0]) > 0))
+        {
+            s_12 = 1;
+        }
+
+        return s_12 + 100;
+    }
+}
\ No newline at end of file
diff --git a/src/tests/JIT/Regression/JitBlue/Runtime_113320/Runtime_113320.csproj b/src/tests/JIT/Regression/JitBlue/Runtime_113320/Runtime_113320.csproj
new file mode 100644
index 00000000000000..de6d5e08882e86
--- /dev/null
+++ b/src/tests/JIT/Regression/JitBlue/Runtime_113320/Runtime_113320.csproj
@@ -0,0 +1,8 @@
+<Project Sdk="Microsoft.NET.Sdk">
+  <PropertyGroup>
+    <Optimize>True</Optimize>
+  </PropertyGroup>
+  <ItemGroup>
+    <Compile Include="$(MSBuildProjectName).cs" />
+  </ItemGroup>
+</Project>