diff --git a/src/Build/BuildCheck/Checks/TargetFrameworkConfusionCheck.cs b/src/Build/BuildCheck/Checks/TargetFrameworkConfusionCheck.cs
index 2c3db3512ad..7d117fe456f 100644
--- a/src/Build/BuildCheck/Checks/TargetFrameworkConfusionCheck.cs
+++ b/src/Build/BuildCheck/Checks/TargetFrameworkConfusionCheck.cs
@@ -46,7 +46,9 @@ private void EvaluatedPropertiesAction(BuildCheckDataContext<EvaluatedProperties
         string? frameworks;
         string? framework;
         if (context.Data.EvaluatedProperties.TryGetValue(PropertyNames.TargetFrameworks, out frameworks) &&
+            !string.IsNullOrEmpty(frameworks) &&
             context.Data.EvaluatedProperties.TryGetValue(PropertyNames.TargetFramework, out framework) &&
+            !string.IsNullOrEmpty(framework) &&
             !context.Data.GlobalProperties.ContainsKey(PropertyNames.TargetFramework))
         {
             // {0} specifies 'TargetFrameworks' property '{1}' and 'TargetFramework' property '{2}'
diff --git a/src/BuildCheck.UnitTests/EndToEndTests.cs b/src/BuildCheck.UnitTests/EndToEndTests.cs
index 08e3fccb43f..489db4af2c1 100644
--- a/src/BuildCheck.UnitTests/EndToEndTests.cs
+++ b/src/BuildCheck.UnitTests/EndToEndTests.cs
@@ -362,6 +362,10 @@ public void WarningsCountExceedsLimitTest(bool buildInOutOfProcessNode, bool lim
     [InlineData("""<TargetFramework>net9.0</TargetFramework>""", "", false)]
     [InlineData("""<TargetFrameworks>net9.0;net472</TargetFrameworks>""", "", false)]
     [InlineData("""<TargetFrameworks>net9.0;net472</TargetFrameworks>""", " /p:TargetFramework=net9.0", false)]
+    [InlineData("""<TargetFramework></TargetFramework><TargetFrameworks>net9.0;net472</TargetFrameworks>""", "", false)]
+    [InlineData("""<TargetFramework /><TargetFrameworks>net9.0;net472</TargetFrameworks>""", "", false)]
+    [InlineData("""<TargetFramework>net9.0</TargetFramework><TargetFrameworks></TargetFrameworks>""", "", false)]
+    [InlineData("""<TargetFramework>net9.0</TargetFramework><TargetFrameworks />""", "", false)]
     [InlineData("""<TargetFramework>net9.0</TargetFramework><TargetFrameworks>net9.0;net472</TargetFrameworks>""", "", true)]
     public void TFMConfusionCheckTest(string tfmString, string cliSuffix, bool shouldTriggerCheck)
     {