diff --git a/recipes/mpdecimal/2.4.2/conanfile.py b/recipes/mpdecimal/2.4.2/conanfile.py
index b5cc04c7adcdc..30ef75727a43f 100644
--- a/recipes/mpdecimal/2.4.2/conanfile.py
+++ b/recipes/mpdecimal/2.4.2/conanfile.py
@@ -30,10 +30,12 @@ def _source_subfolder(self):
     _autotools = None
 
     def configure(self):
-        if self.settings.arch not in ("x86", "x86_64"):
+        if self.settings.os != "Macos" and self.settings.arch not in ("x86", "x86_64"):
             raise ConanInvalidConfiguration("Arch is unsupported")
         del self.settings.compiler.libcxx
         del self.settings.compiler.cppstd
+        if self.options.shared:
+            del self.options.fPIC
 
     def config_options(self):
         if self.settings.os == "Windows":
@@ -161,6 +163,8 @@ def _configure_autotools(self):
         if self._autotools:
             return self._autotools
         self._autotools = AutoToolsBuildEnvironment(self, win_bash=tools.os_info.is_windows)
+        if self.settings.os == "Macos" and self.settings.arch == "armv8":
+            self._autotools.link_flags.append("-arch arm64")
         self._autotools .configure()
         return self._autotools
 
diff --git a/recipes/mpdecimal/2.5.x/conanfile.py b/recipes/mpdecimal/2.5.x/conanfile.py
index dbb649446394a..5c34e916decbc 100644
--- a/recipes/mpdecimal/2.5.x/conanfile.py
+++ b/recipes/mpdecimal/2.5.x/conanfile.py
@@ -55,7 +55,7 @@ def build_requirements(self):
                 self.build_requires("msys2/cci.latest")
 
     def validate(self):
-        if self.settings.arch not in ("x86", "x86_64"):
+        if self.settings.os != "Macos" and self.settings.arch not in ("x86", "x86_64"):
             raise ConanInvalidConfiguration("Arch is unsupported")
         if self.options.cxx:
             if self.options.shared and self.settings.os == "Windows":
@@ -123,10 +123,14 @@ def _configure_autotools(self):
         if self._autotools:
             return self._autotools
         self._autotools = AutoToolsBuildEnvironment(self, win_bash=tools.os_info.is_windows)
+        conf_vars = self._autotools.vars
+        if self.settings.os == "Macos" and self.settings.arch == "armv8":
+            conf_vars["LDFLAGS"] += " -arch arm64"
+            conf_vars["LDXXFLAGS"] = "-arch arm64"
         conf_args = [
             "--enable-cxx" if self.options.cxx else "--disable-cxx"
         ]
-        self._autotools.configure(args=conf_args)
+        self._autotools.configure(args=conf_args, vars=conf_vars)
         return self._autotools
 
     @property
diff --git a/recipes/mpdecimal/2.5.x/test_package/CMakeLists.txt b/recipes/mpdecimal/2.5.x/test_package/CMakeLists.txt
index 0207168301a5f..f452aa64e4430 100644
--- a/recipes/mpdecimal/2.5.x/test_package/CMakeLists.txt
+++ b/recipes/mpdecimal/2.5.x/test_package/CMakeLists.txt
@@ -4,6 +4,11 @@ project(test_package)
 include("${CMAKE_BINARY_DIR}/conanbuildinfo.cmake")
 conan_basic_setup(TARGETS)
 
+# Workaround for -rpath on arm64: https://cmake.org/cmake/help/latest/release/3.20.html#id2
+if(CMAKE_VERSION VERSION_LESS "3.20.1" AND CMAKE_OSX_ARCHITECTURES STREQUAL "arm64")
+    set(CMAKE_SHARED_LIBRARY_RUNTIME_C_FLAG "-Wl,-rpath,")
+endif()
+
 # This is a non-official mpdecimal module!
 find_package(mpdecimal REQUIRED)